Luminal Chloride-dependent Activation of Endosome Calcium Channels

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Luminal chloride-dependent activation of endosome calcium channels: patch clamp study of enlarged endosomes.

Although Ca(2+) release from early endosomes (EE) is important for the fusion of primary endosomes, the presence of an ion channel responsible for releasing calcium from the EE has not been shown. A recent proteomics study has identified the TRPV2 channel protein in EE, suggesting that transient receptor potential-like Ca(2+) channels may be in endosomes. The submicron size of endosomes has mad...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 2007

ISSN: 0021-9258

DOI: 10.1074/jbc.m702557200